Web26 Apr 2012 · Centromeric ultrafine anaphase bridges are physiological DNA structures thought to contain unresolved DNA catenations between the centromeres separating during anaphase. BLM and PICH helicases colocalize at these ultrafine anaphase bridges and promote their resolution. Web1 Jan 2024 · Ultrafine anaphase bridges (UFBs) are thin DNA threads linking the separating sister chromatids in the anaphase of mitosis. UFBs are thought to form when topological …
Processing DNA lesions during mitosis to prevent genomic …
Web16 Jul 2015 · There are two types of sister-chromatid anaphase bridges: chromatin bridges, consequences of defective sister chromatid segregation , can be stained with conventional dyes, such as DAPI; and ultrafine anaphase bridges (UFBs), which cannot be stained with conventional DNA dyes or antibodies against histones [8, 9]. UFBs were discovered only … WebEventually, in mitosis, they can evolve into ultrafine anaphase bridges (UFBs) connecting sister chromatids, which can finally lead to chromosomal instability. In the following sections, we focus on CFSs as an example of the extraordinary processes that cells carry out in mitosis to resolve problems that originated during the previous S-phase, in order to … introduction to optimum design 1989
The origins and processing of ultra fine anaphase DNA bridges
Web18 Dec 2024 · We find that intermediates persist until mitosis and form a distinct class of anaphase bridges, which we term homologous recombination ultra-fine bridges (HR-UFBs). Web(A) HeLa cells were transfected with siControl or siTDP-43 and ultrafine anaphase bridges (UFBs) were visualized using both anti-PICH and anti-BLM antibodies. Representative … WebIntriguingly replication fork stalling and DNA breakage correlate with the appearance of structures that are analogous to ultrafine anaphase bridges (UFBs), which frequently form … new orleans jesuit high school